Scandinavian Journal of Pain
Volume 1, Issue 3 , Page 142 , July 2010

Repeated nociceptive stimulation for detecting drug effects

References 

  1. Woolf CJ. Long term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat. Pain. 1984;18:325–343
  2. Dickenson AH, Sullivan AF. Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation. Neuropharmacology. 1987;26:1235–1238
  3. Price DD. Characteristics of second pain and flexion reflexes indicative of prolonged central summation. Exp Neurol. 1972;37:371–387
  4. Arendt-Nielsen L, Brennum J, Sindrup S, Bak P. Electrophysiological and psychophysical quantification of central temporal summation of the human nociceptive system. Eur J Appl Physiol. 1994;68:266–273
  5. Price DD, Long S, Huitt C. Sensory testing of pathophysiological mechanisms of pain in patients with reflex sympathetic dystrophy. Pain. 1992;49:163–173
  6. Curatolo M, Petersen-Felix S, Arendt-Nielsen L, Giani C, Zbinden AM, Radanov BP. Central hypersensitivity in chronic pain after whiplash injury. Clin J Pain. 2001;17:306–315
  7. Price D, Staud R, Robinson M, Mauderli A, Cannon R, Vierck C. Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients. Pain. 2002;99:49–59
  8. Enggaard TP, Mikkelsen SS, Zwisler ST, Klitgaard NA, Sindrup SH. The effects of gabapentin in human experimental pain models. Scand J Pain. 2010;1:143–148
  9. Arendt-Nielsen L, Frokjaer JB, Staahl C, Graven-Nielsen T, Huggins JP, Smart TS, et al. Effects of gabapentin on experimental somatic pain and temporal summation. Reg Anesth Pain Med. 2007;32:382–388
  10. Arendt-Nielsen L, Petersen-Felix S, Fischer M, Bak P, Bjerring P, Zbinden AM. The effect of N-methyl-D-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli: a placebo-controlled experimental human study. Anesth Analg. 1995;81:63–68
  11. Staahl C, Olesen AE, Andresen T, Arendt-Nielsen L, Drewes AM. Assessing analgesic actions of opioids by experimental pain models in healthy volunteers—an updated review. Br J Clin Pharmacol. 2009;68:149–168
  12. Staahl C, Olesen AE, Andresen T, Arendt-Nielsen L, Drewes AM. Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers: an updated review. Br J Clin Pharmacol. 2009;68:322–341
  13. Arendt-Nielsen L, Curatolo M, Drewes A. Human experimental pain models in drug development: translational pain research. Curr Opin Investig Drugs. 2007;8:41–53

PII: S1877-8860(10)00010-8

doi: 10.1016/j.sjpain.2010.01.008

Scandinavian Journal of Pain
Volume 1, Issue 3 , Page 142 , July 2010